Kurtz’s coefficient criterion
If a polynomial has positive coefficients and $a_k^2 > 4a_{k-1}a_{k+1}$ at every interior index, then all its roots are real and distinct.
References
D. C. Kurtz, “A sufficient condition for all the roots of a polynomial to be real,” American Mathematical Monthly 99 (1992), 259–263. See also the contextual account on symmetricfunctions.com.